Scroll through any online mushroom shop and you'll find a dozen bottles of psilocybin microdose capsules. One says 100mg. Another says 250mg. One lists lion's mane and cordyceps. Another is just "Golden Teacher" and nothing else. Prices range from under $30 to over $70.
It's easy to grab the one with the nicest label. A better approach is knowing what each number and ingredient means so you can pick the bottle that fits how you actually plan to microdose. This guide covers what to compare.
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Start With the Milligrams
Capsule strength is usually listed as milligrams of dried mushroom per capsule. Common strengths include 100mg, 150mg, 200mg, and 250mg.
Lower-strength capsules give you more flexibility. If you find a 100mg capsule too subtle, you can take two. If you start with a 250mg capsule and it's more than you want, you can't easily split it. For that reason, many experienced microdosers suggest beginners buy a lower strength first and adjust from there.
Single-Ingredient vs. Stacked Formulas
This is the biggest difference between products on the market.
Single-ingredient capsules contain only ground psilocybin mushroom. You know exactly what you're taking, which makes it easier to track how a specific strain agrees with you.
Stacked capsules combine psilocybin mushroom with other ingredients. Common additions include:
- Lion's mane: A functional mushroom popular in coffee blends and supplements
- Cordyceps: Often included in "energy" or morning-focused formulas
- Reishi: Found in blends marketed for evening or winding down
- Niacin (vitamin B3): Part of the well-known Stamets Stack
Stacked blends aren't better or worse. They're a different product. If you already take lion's mane in another form, a single-ingredient capsule avoids doubling up.
Check the Strain
Brands that name the strain are giving you useful information. Golden Teacher is the most common choice for microdose capsules because it's widely available and well-known. Penis Envy is more potent by weight, so a 100mg Penis Envy capsule may feel stronger than a 100mg Golden Teacher capsule. Some brands use a blend of strains, which is fine as long as it's disclosed.
Capsule Shell Type
Most microdose capsules use one of two shells. Vegetable cellulose (often listed as HPMC) is plant-based and suits vegan and vegetarian buyers. Gelatin shells are animal-derived. Both dissolve at similar rates, so this comes down to personal preference.
Calculate Price Per Dose
The sticker price doesn't tell the full story. A bottle of 30 capsules at $45 costs $1.50 per capsule. A bottle of 20 at $35 costs $1.75. Then factor in how many capsules you'll take per dose.
Here's a quick way to compare two bottles:
- Divide the price by the number of capsules.
- Multiply by how many capsules you'll take each dosing day.
- Multiply by the number of dosing days in your schedule for a month.
That monthly number is the real cost, and it often changes which bottle looks like the better deal.
Signs of a Well-Made Product
Look for a batch or lot number, a production or best-before date, and a complete ingredient list including any fillers. Rice flour is a common filler used to bring small doses up to capsule volume. Its presence isn't a problem, but it should be listed.
A brand that answers customer questions promptly and specifically is usually one that pays attention to what goes into the bottle as well.